課程名稱:生物資訊分析課程
指導老師:鄧致剛
- Jan 20 Thu 2011 20:26
生物資訊期末報告 微生物組 M9901230 詹志勇
- Jan 20 Thu 2011 18:31
Introduction of BIRC5
The BIRC5 protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of survivin induction pathways leading to increase in apoptosis and decrease in tumour growth. The BIRC5 protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.This fact therefore makes BIRC5 an ideal target for cancer therapy as cancer cells are targeted while normal cells are left alone. BIRC5 expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that BIRC5 localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. The molecular mechanisms of BIRC5 regulation are still not well understood, but regulation of BIRC5 seems to be linked to the p53 protein. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.
- Jan 24 Mon 2011 00:58
BIRC5之phylogenetics tree
- Jan 23 Sun 2011 22:32
BIRC5的protein post-translational modification
- Jan 23 Sun 2011 22:15
BIRC5之PI,Mw
- Jan 23 Sun 2011 22:02
BIRC5 fromfasta的序列
- Jan 23 Sun 2011 20:54
BIRC5 protein structure
- Jan 21 Fri 2011 12:21
利用SMS找出BIRC5的ORF